Should be able to fit interface on screens that users customize DPI, whether 100, 115, 125, 130% DPI, it should fit, that is basic programming 97% of applications have.

I set my screen at a custom 115% DPI, it's a 22 inch widescreen LCD, and 100% DPI is too small for my eyes. Digital Diary 4.6 cuts off all of the button graphics and text because of this. My experience has been that the vast majority of software and applications automatically adjust for this, and only an extremely small percentage of inexperienced programmers do not plan for this when creating a new app. Then the text disappears under larger layers of the GUI, and buttons and other necessary graphical representations are hidden from view under other layers of the interface. It makes for an annoying and unenjoyable experience when using the software, and some critical functions can be hidden from view entirely. Users access this feature when right-clicking on the desktop, and clicking on "Screen Resolution" on Windows 7, I forget the exact phrasing, but the route is similar for Vista and Windows XP Pro, they simply involve right-clicking on the desktop if you don't want to go through the Control Panel.